Key result
Fine-needle aspiration, histology, and FISH assay successfully established the diagnosis of primary Ewing sarcoma/primitive neuroectodermal tumor of the kidney in a 34-year-old man.
Case Report (n=1)
This case report demonstrates the utility of fine-needle aspiration, histology, and FISH assay in diagnosing primary Ewing sarcoma/PNET of the kidney.
May support FNA diagnosis of rare renal Ewing sarcoma/PNET; leaves open need for larger series before practice change.
A 34-year-old previously healthy Hispanic man presented with lower back pain. CT scan revealed an 8-cm space-occupying lesion in the superior pole of the left kidney with numerous small lytic lesions in the skull, vertebrae, ribs, and pelvic bones. CT-guided fine-needle aspiration biopsy revealed a high-grade primitive small round cell tumor with the tumor cells being strongly positive for CD99 and vimentin. The patient subsequently underwent a left nephrectomy. Fluorescence in situ hybridization analysis using a DNA probe for the Ewing Sarcoma breakpoint region 1 (EWSR1) on chromosome 22g12 revealed a rearrangement of the EWSR1 locus. The diagnosis of primary Ewing sarcoma/primitive neuroectodermal tumor of the kidney was established.
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Kang et al. (2007) conducted a case report in Primary Ewing sarcoma/primitive neuroectodermal tumor of the kidney (n=1). Fine-needle aspiration, histology, and FISH Assay was evaluated. Fine-needle aspiration, histology, and FISH assay successfully established the diagnosis of primary Ewing sarcoma/primitive neuroectodermal tumor of the kidney in a 34-year-old man.
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