What question did this study set out to answer?

To review differentially regulated microRNAs between males and females and examine how sex-specific regulatory mechanisms influence disease susceptibility, progression, and treatment.

January 1, 2014Biology of Sex DifferencesOpen Access

Influence of sex differences on microRNA gene regulation in disease

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Authors

SSSalil SharmaJohns Hopkins University MEMansoureh EghbaliUniversity of California, Los Angeles

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Implication

Review highlights sex-biased microRNA regulation in human diseases, suggesting critical opportunities for developing sex-specific therapeutic strategies.

Key Points

To review differentially regulated microRNAs between males and females and examine how sex-specific regulatory mechanisms influence disease susceptibility, progression, and treatment.
Synthesized literature on sexual dimorphism, sex hormones, and X-linked genetic factors influencing microRNA expression.
Assessed microRNA regulation across major sexually dimorphic conditions, including cardiovascular, neurological, and autoimmune disorders.
MicroRNA expression varies between sexes due to direct regulation by sex steroid hormones and X-linked genes.
Differentially regulated microRNAs contribute to observable disparities in disease prevalence, progression, and severity between males and females.
The role of microRNAs in sex-biased disease remains understudied, underscoring an unmet need for targeted, sex-specific microRNA therapies.

Cite This Study

Sharma et al. (2014) studied this question.

synapsesocial.com/papers/6a6f1e7835aa2c282ce0850c https://doi.org/10.1186/2042-6410-5-3

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Implication

Review highlights sex-biased microRNA regulation in human diseases, suggesting critical opportunities for developing sex-specific therapeutic strategies.

Influence of sex differences on microRNA gene regulation in disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Influence of sex differences on microRNA gene regulation in disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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