Key result
Metabolic syndrome significantly increased the risk of postoperative atrial fibrillation and major adverse cardiovascular and cerebrovascular events over a 3-year period after CABG surgery.
Why the study?
Does metabolic syndrome increase the risk of postoperative atrial fibrillation and MACCE in patients undergoing isolated CABG?
Cohort (n=460)
Does metabolic syndrome increase the risk of postoperative atrial fibrillation and MACCE in patients undergoing isolated CABG?
Metabolic syndrome is an independent risk factor for postoperative atrial fibrillation and MACCE up to 3 years after isolated CABG surgery.
Supports closer post-CABG monitoring in metabolic syndrome; hypothesis-generating for targeted interventions to reduce AF and MACCE.
BACKGROUND: We sought to investigate the influence of the metabolic syndrome (MS) on new-onset postoperative atrial fibrillation (POAF), and occurrence of major adverse cardiovascular and cerebrovascular events (MACCE) in a period of 3 years after isolated coronary artery bypass grafting (CABG) surgery. METHODOLOGY: The study included 460 patients who underwent the first CABG operation without baseline atrial fibrillation. The MS was defined by the presence of three or more Adult Treatment Panel (ATP)-American Heart Association (AHA)- National Heart, Lung, and Blood (NHLB) Institute criteria. POAF was diagnosed by continuous electrocardiographic monitoring during the first 48 to 72 hours after CABG. All the patients were followed up for at least 3 years after surgery. RESULTS: The MS and its criteria were significantly associated with POAF and MACCE occurrence in the 3-year period after isolated CABG surgery. Among the MS risk factors, hypertension, abdominal obesity, and the increased fasting glucose level were independently associated with both POAF and MACCE onset in the observed patients. Individuals with four or five MS criteria have similar risk of POAF or MACCE as individuals with three MS criteria. In the 3-year period of follow-up, the MS was proven to be associated with MACCE occurrence, independently of hypertension, diabetes, and obesity defined by body mass index. CONCLUSIONS: The MS and its criteria significantly increased risk of POAF and MACCE in a 3-year period. The MS, irrespective of hypertension, diabetes, and obesity, was associated with POAF and MACCE in the patients who underwent CABG.
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Ivanović et al. (2014) conducted a cohort in Patients undergoing first CABG (n=460). Metabolic syndrome vs. Absence of metabolic syndrome was evaluated on New-onset postoperative atrial fibrillation (POAF) and major adverse cardiovascular and cerebrovascular events (MACCE). Metabolic syndrome significantly increased the risk of postoperative atrial fibrillation and major adverse cardiovascular and cerebrovascular events over a 3-year period after CABG surgery.