Key result
Postoperative atrial fibrillation after CABG was associated with significantly higher long-term mortality (HR 3.3; 95% CI 0.04-10.8; P=0.04) and morbidity (HR 4.0; 95% CI 2.35-6.96; P=0.001).
Why the study?
Does postoperative atrial fibrillation increase long-term mortality and morbidity in patients undergoing isolated CABG?
Cohort (n=989)
Does postoperative atrial fibrillation increase long-term mortality and morbidity in patients undergoing isolated CABG?
Hazard Ratio: 3.3 (95% CI 0.04–10.8)
p-value: p=0.04
Postoperative atrial fibrillation after isolated CABG is a strong predictor of higher long-term mortality and morbidity.
POAF after CABG signals elevated long-term risk; hypothesis-generating and requires prospective trials before changing practice.
BACKGROUND: Atrial fibrillation (AF) after coronary artery bypass graft (CABG) is a common complication with potentially higher risk of adverse outcome and prolonged hospital stay. OBJECTIVE: To determine the impact of postoperative AF (POAF) on long-term outcome in a large cohort of patients who underwent CABG. PATIENTS AND METHODS: We conducted an observational cohort study of 989 patients who underwent isolated CABG with more than 5-year follow-up. Patient divided in two groups: patients with and without POAF. RESULTS: In this study, atrial fibrillation developed after CABG in 156 patients (15.8%). Patients with POAF were generally older (P = 0.001) and presented more often with comorbidities including congestive heart failure (P = 0.001), hypertension (P = 0.001), peripheral vascular disease (P = 0.001), hyperlipidemia (P = 0.009), and renal failure (P = 0.001). Five-year mortality was observed in 23 (2.3%) patients. Patients with POAF had higher five-year mortality rate than those without POAF. Multivariate logistic analysis showed that AF after surgery has a strong effect on mortality (HR, 3.3; 95% CI, 0.04-10.8, P = 0.04) and morbidity rates (HR, 4.0; 95% CI, 2.35-6.96, P = 0.001). CONCLUSIONS: Postoperative atrial fibrillation strongly predicts higher long-term mortality and morbidity following coronary artery bypass graft.
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Haghjoo et al. (2012) conducted a cohort in Coronary artery bypass graft surgery (n=989). Postoperative atrial fibrillation vs. No postoperative atrial fibrillation was evaluated on Mortality (HR 3.3, 95% CI 0.04-10.8, p=0.04). Postoperative atrial fibrillation after CABG was associated with significantly higher long-term mortality (HR 3.3; 95% CI 0.04-10.8; P=0.04) and morbidity (HR 4.0; 95% CI 2.35-6.96; P=0.001).
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