Low cholesterol concentrations and severe depressive symptoms in elderly people
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Key result
Low cholesterol concentration (< 4.14 mmol/l) was not significantly associated with severe depressive symptoms in older adults after adjusting for health-related factors.
Why the study?
Is low serum cholesterol concentration associated with severe depressive symptoms in elderly people?
Population
3939 men and women aged >= 71 from three communities of the established populations for epidemiologic…
Comparison
Low serum cholesterol concentration vs Normal or higher serum cholesterol concentration
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
No independent association after adjustment cautions against unadjusted links; leaves open any causal role of low cholesterol in elderly depression.
Study Design
Type
Cross-Sectional (n=3,939)
Multicenter
Yes
Structured PICO
Is low serum cholesterol concentration associated with severe depressive symptoms in elderly people?
P
Population
3,939 men and women aged ≥71 from three communities were assessed to investigate the association between low serum cholesterol concentration and severe depressive symptoms.
E
Exposure
Low serum cholesterol concentration (< 4.14 mmol/l)
C
Comparator
Normal or higher serum cholesterol concentration
O
Outcome
Score of depressive symptoms on the Centers for Epidemiologic Studies' depression scalepatient reported
Main Result
Effect estimate: OR 1.9 (men), OR 1.8 (women) (95% CI 1.1-3.3 (men), 1.1-2.9 (women))
The apparent association between low cholesterol and severe depressive symptoms in the elderly is confounded by health-related factors and is not significant after adjustment.
Cite This Study
Brown et al. (1994) conducted a cross-sectional in Severe depressive symptoms (n=3,939). Low cholesterol concentration (< 4.14 mmol/l) vs. Higher cholesterol concentrations was evaluated on Score of depressive symptoms on the Centers for Epidemiologic Studies' depression scale (severe defined as score ≥16) (OR 1.9 (men), OR 1.8 (women), 95% CI 1.1-3.3 (men), 1.1-2.9 (women)). Low cholesterol concentration (< 4.14 mmol/l) was not significantly associated with severe depressive symptoms in older adults after adjusting for health-related factors.
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