October 1, 1992Arteriosclerosis and Thrombosis A Journal of Vascular Biology

Familial combined hyperlipidemia and abnormal lipoprotein lipase.

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Population

56 subjects with familial combined hyperlipidemia, comprising 9 with established diagnosis by family…

Design

Cross-sectional

Authors

SBStephan P. BabirakMaine Medical Center BBB. Greg BrownGeneral / Preventive / Lipids JBJohn D. BrunzellPreventive Cardiology

Discussion

Member takes

Implication

Supports FCHL subclassification by LPL activity; leaves open whether LPL modulation alters lipid-driven risk.

Structured PICO

Population

56 subjects with familial combined hyperlipidemia (FCHL), comprising 9 with established diagnosis by family studies, 14 clinic patients with tentative diagnosis, and 33 undergoing angiography with CAD and FCHL diagnosis by family study.

Outcome

Lipoprotein lipase (LPL) activity and associated lipoprotein abnormalities (plasma triglyceride and HDL cholesterol levels)surrogate

A subset of patients with familial combined hyperlipidemia (FCHL) have reduced lipoprotein lipase activity, which is associated with higher triglycerides and lower HDL cholesterol.

Cite This Study

Babirak et al. (1992) studied this question.

synapsesocial.com/papers/6a6f23ba22b3175134db417f https://doi.org/10.1161/01.atv.12.10.1176

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Familial combined hyperlipidemia and abnormal lipoprotein lipase.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Familial combined hyperlipidemia and abnormal lipoprotein lipase.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider