July 23, 2003Journal of Lipid ResearchOpen Access

Determinants of low HDL levels in familial combined hyperlipidemia

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Population

228 subjects from 49 familial combined hyperlipidemia families, including 88 affected family members, 88…

Design

Cross-sectional

Authors

ASAino SoroVTT Technical Research Centre of Finland MJMatti JauhiainenPreventive Cardiology CEChristian EhnholmGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Reduced HDL2 in FCHL families associates with higher hepatic lipase; hypothesis-generating and should not change practice.

Structured PICO

Population

228 subjects from 49 familial combined hyperlipidemia (FCHL) families, including 88 affected family members, 88 unaffected family members, and 52 spouses.

Comparator

Unaffected family members (n=88) and spouses (n=52)

Outcome

Levels of HDL cholesterol, HDL2 cholesterol, HDL3 cholesterol, apolipoprotein A-I, and postheparin plasma activities of hepatic lipase (HL), lipoprotein lipase, cholesterol ester transfer protein, and phospholipid transfer protein (PLTP)surrogate

In familial combined hyperlipidemia, triglyceride enrichment of HDL particles and enhanced hepatic lipase activity are associated with reduced HDL and HDL2 cholesterol levels.

Cite This Study

Soro et al. (2003) studied this question.

synapsesocial.com/papers/6a82c309d5ea960236d4a42d https://doi.org/10.1194/jlr.m300069-jlr200

View Full Paper

Ask AI

Bookmark

Determinants of low HDL levels in familial combined hyperlipidemia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Determinants of low HDL levels in familial combined hyperlipidemia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider