Population
444 individuals with familial combined hyperlipidaemia from two cohorts
Design
Cohort
Follow-up
5 years
Authors
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May inform FCHL diagnosis via apoB rather than LDL-C in males; hypothesis-generating from observational data and needs prospective confirmation.
A parabolic relationship between plasma triacylglycerols and LDL-cholesterol explains the multiple-type hyperlipidaemia in FCHL, supporting the use of apoB over LDL-C for diagnosis and cardiovascular risk prediction.
Brouwers et al. (2008) studied this question.
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