What question did this study set out to answer?

To review and compare experimental animal models used to investigate both direct and indirect pharmacological effects on coronary circulation.

January 1, 1986Drug Development Research

Animal models to investigate drug effects on coronary physiology

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Population

Animal models for studying coronary physiology

Design

Review

Authors

CJCarl E. JonesAdvanced Research Institute PGPatricia A. GwirtzUniversity of North Texas

Discussion

Member takes

Implication

Conscious instrumented animals offer superior physiologic fidelity for coronary studies; extends model comparisons while leaving optimal protocols open.

Key Points

To review and compare experimental animal models used to investigate both direct and indirect pharmacological effects on coronary circulation.
Evaluated in vitro and ex vivo systems, including isolated vascular rings and isolated perfused hearts.
Assessed in vivo approaches using anesthetized animals receiving intracoronary drug infusions.
Analyzed intact conscious, instrumented animal models monitored during targeted intracoronary drug administration.
Isolated vessel setups allow precise environmental control but typically evaluate conduit vessels rather than true resistance microvasculature.
Isolated heart and anesthetized animal preparations capture myocardial interactions and broader hemodynamic variables alongside vascular responses.
Conscious, instrumented animal models provide the highest physiological fidelity for isolating coronary drug actions from anesthesia artifacts.

Structured PICO

Population

Animal models for studying coronary physiology (isolated vessels, isolated hearts, in vivo anesthetized animals, conscious instrumented animals)

Intervention

Drug administration (including intracoronary)

Outcome

Drug effects on coronary circulation and secondary effects on myocardium/cardiac variables

This review highlights the utility and limitations of various animal models, from isolated vessels to conscious instrumented animals, for investigating pharmacological effects on coronary physiology.

Cite This Study

Jones et al. (1986) studied this question.

synapsesocial.com/papers/6a6f23fe8031ec7bb1db9d12 https://doi.org/10.1002/ddr.430070102

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Implication

Conscious instrumented animals offer superior physiologic fidelity for coronary studies; extends model comparisons while leaving optimal protocols open.

Animal models to investigate drug effects on coronary physiology

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Animal models to investigate drug effects on coronary physiology

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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