November 1, 1979Journal of Cardiovascular Pharmacology

Regional Myocardial Perfusion and Wall Thickness and Arteriovenous Shunting After Ergotamine Administration to Pigs with a Fixed Coronary Stenosis

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Why the study?

Does ergotamine worsen myocardial perfusion or hemodynamics in pigs with acute coronary stenosis?

Population

Pigs with normal myocardial circulation or with acute coronary stenosis

Comparison

Ergotamine vs Baseline/ischemic state prior to ergotamine…

Design

Preclinical

Authors

HSH. C. SCHAMHARDTUtrecht University PVPieter D. VerdouwCross-Cutting Cardiology THTeun M. van der HoekErasmus University Rotterdam

Discussion

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Implication

Challenges absolute CAD contraindication in this porcine model only; leaves open human translation and requires prospective study.

Structured PICO

Does ergotamine worsen myocardial perfusion or hemodynamics in pigs with acute coronary stenosis?

Population

Pigs with normal myocardial circulation or with acute coronary stenosis (clamp on the left anterior descending coronary artery)

Intervention

Ergotamine (8, 16, and 32 micrograms/kg i.v. in normal pigs; 8 micrograms/kg i.v. in pigs with acute coronary stenosis)

Comparator

Baseline/ischemic state prior to ergotamine administration

Outcome

Hemodynamic parameters (heart rate, cardiac output, aortic blood pressure, systemic vascular resistance) and regional myocardial perfusion (blood flow, endo/epi flow ratio)surrogate

Ergotamine administration in a porcine model of acute coronary stenosis improved myocardial perfusion to the ischemic zone without worsening functional parameters, challenging its absolute contraindication in coronary artery disease.

Cite This Study

SCHAMHARDT et al. (1979) studied this question.

synapsesocial.com/papers/6a6f23ff8031ec7bb1db9d16 https://doi.org/10.1097/00005344-197911000-00008

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Regional Myocardial Perfusion and Wall Thickness and Arteriovenous Shunting After Ergotamine Administration to Pigs with a Fixed Coronary Stenosis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regional Myocardial Perfusion and Wall Thickness and Arteriovenous Shunting After Ergotamine Administration to Pigs with a Fixed Coronary Stenosis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider