Key result
Ergotamine tartrate significantly increased local subcutaneous blood flow during limb elevation to +20 and +40 cm in both normal subjects and migraine patients (P=0.01 and P=0.02).
Why the study?
Does single-dose ergotamine tartrate alter local regulation of subcutaneous blood flow in normal subjects and migraine patients?
Population
15 normal subjects and 9 migraine patients
Comparison
0.5 mg ergotamine tartrate/70 kg body weight i.v. vs Baseline and normal subjects
Design
Other
Follow-up
3 hours
Authors
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Ergotamine may alter local blood flow regulation via veno-arteriolar reflex; leaves open clinical relevance for migraine and requires prospective validation.
Does single-dose ergotamine tartrate alter local regulation of subcutaneous blood flow in normal subjects and migraine patients?
p-value: p=0.01 and 0.02
Ergotamine alters local blood flow regulation during limb elevation, suggesting its veno-constrictor effect triggers tension receptors of the veno-arteriolar reflex even at heart level.
Eickhoff et al. (1982) studied Migraine (n=24). Ergotamine tartrate vs. Baseline (before ergotamine) was evaluated on Blood flow during elevation to +20 and to +40 cm (p=0.01 and 0.02). Ergotamine tartrate significantly increased local subcutaneous blood flow during limb elevation to +20 and +40 cm in both normal subjects and migraine patients (P=0.01 and P=0.02).
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