Key result
Prophylactic and therapeutic anticoagulation can be considered in patients with platelet disorders who have high thrombotic risk, provided that individual bleeding and thrombotic risks are carefully balanced.
Why the study?
Patients with platelet disorders can develop prothrombotic conditions requiring anticoagulation, raising concern that anticoagulation bleeding risks could compound the hemorrhagic risk of the underlying platelet defect.
This review provides a practical framework for balancing thrombotic and bleeding risks when prescribing prophylactic or therapeutic anticoagulation to patients with platelet disorders.
Supports individualized anticoagulation decisions in high-thrombotic-risk platelet disorders; leaves open need for prospective trials.
Platelet disorders comprise heterogeneous diseases featured by reduced platelet counts and/or impaired platelet function causing variable bleeding symptoms. Despite their bleeding diathesis, patients with platelet disorders can develop transient or permanent prothrombotic conditions that necessitate prophylactic or therapeutic anticoagulation. Anticoagulation in patients with platelet disorders is a matter of concern because the bleeding risk could add to the hemorrhagic risk related to the platelet defect. This review provides an overview on the evidence on anticoagulation in patients with acquired and inherited thrombocytopenia and/or platelet dysfunction. We summarize tools to evaluate and balance bleeding- and thrombotic risks and describe a practical approach on how to manage these patients if they have an indication for prophylactic or therapeutic anticoagulation.
No takes yet. Share an insight, caveat, or question.
Zaninetti et al. (2021) conducted a review in Platelet disorders requiring anticoagulation. Anticoagulation was evaluated. Prophylactic and therapeutic anticoagulation can be considered in patients with platelet disorders who have high thrombotic risk, provided that individual bleeding and thrombotic risks are carefully balanced.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: