Why the study?
Does dalteparin prevent postoperative thromboembolism compared to unfractionated heparin in patients undergoing pelvic or abdominal surgery for cancer?
Population
80 patients undergoing pelvic or abdominal surgery for cancer
Comparison
Dalteparin 5000 anti-Xa U/day for 10 days vs Unfractionated heparin 15,000 IU/day for 10 days
Design
RCT, Randomized in two groups
Follow-up
10 days
Authors
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Simplifies VTE prophylaxis in cancer surgery with once-daily dosing; confirms LMWH preference over UFH for safety.
Does dalteparin prevent postoperative thromboembolism compared to unfractionated heparin in patients undergoing pelvic or abdominal surgery for cancer?
A single daily dose of low molecular weight heparin (dalteparin) is as effective as three daily doses of unfractionated heparin for thromboembolism prophylaxis in abdominal oncological surgery, with a better safety profile regarding minor and moderate bleeding.
Jp et al. (1988) studied this question.
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