Why the study?
Does an enzyme profile including creatine phosphokinase, serum lactic acid dehydrogenase, and hydroxy butyrate dehydrogenase improve the specificity of diagnosing pulmonary infarction?
Does an enzyme profile including creatine phosphokinase, serum lactic acid dehydrogenase, and hydroxy butyrate dehydrogenase improve the specificity of diagnosing pulmonary infarction?
A specific profile of cardiac and metabolic enzymes can help differentiate pulmonary infarction from myocardial infarction.
May enhance specificity distinguishing pulmonary from myocardial infarction; hypothesis-generating and requires prospective validation before clinical use.
The diagnosis of pulmonary infarction is dependent upon the use of multiple diagnostic criteria. These include clinical findings, electrocardiographic changes, pulmonary function changes, serial enzyme change, and radiographic techniques. Increased specificity in the diagnosis of pulmonary infarction was found with a profile of enzyme studies including determinations of creatine phosphokinase, serum lactic acid dehydrogenase, and hydroxy butyrate dehydrogenase. The values obtained from a study of this combination of enzymes eliminated patients whose symptomatology simulated pulmonary infarction but actually represented myocardial infarction. The use of isoenzymes was of minimal value in differential diagnosis of this condition.
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Eugene L. Coodley (1969) studied this question.
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