Population
Single fibres of the anterior tibialis muscle of the frog, Rana temporaria
Design
Preclinical
Authors
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Caution against extrapolating frog fiber data to human myocardium; extends Huxley model but leaves open cardiac translation.
In frog muscle fibers, maximum shortening velocity is significantly higher early in a tetanic contraction compared to the plateau phase, consistent with the Huxley cross-bridge model.
Josephson et al. (1998) studied this question.
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