What question did this study set out to answer?

To evaluate the impact of deuterium oxide on the isometric contraction and mechanical properties of skeletal muscle.

September 1, 1961Acta Physiologica Scandinavica

The Effect of Deuterium Oxide on the Mechanical Properties of Muscle

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Authors

OSOle SvensmarkUniversity of Copenhagen

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Implication

Experimental study demonstrates that deuterium oxide impairs force development in isolated frog muscle, suggesting disruption of excitation-contraction coupling or contractile machinery.

Key Points

To evaluate the impact of deuterium oxide on the isometric contraction and mechanical properties of skeletal muscle.
Assessed isometric twitch and tetanic contractions of isolated frog muscle preparations exposed to 99.8% deuterium oxide relative to aqueous Ringer solution.
Measured twitch and tetanic tension, latency, rate of force development, active state duration, and action potential conduction time.
Twitch force was reduced to 2–70% of control values in aqueous Ringer, the rate of force development dropped to 12–30%, and the latency of force development approximately doubled, while total twitch duration remained unchanged.
Tetanic force was reduced to 61–96%, with accelerated decline of the active state and a lower stimulation frequency required to maintain complete tetanus, despite normal action potential conduction times.

Cite This Study

Ole Svensmark (1961) studied this question.

synapsesocial.com/papers/6a6f27f626a7f98052dbe54e https://doi.org/10.1111/j.1748-1716.1961.tb02265.x

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Implication

Experimental study demonstrates that deuterium oxide impairs force development in isolated frog muscle, suggesting disruption of excitation-contraction coupling or contractile machinery.

The Effect of Deuterium Oxide on the Mechanical Properties of Muscle

Discussion

Member takes

Implication

Key Points

Cite This Study

The Effect of Deuterium Oxide on the Mechanical Properties of Muscle

Discussion

Member takes

Implication

Key Points

Cite This Study

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