Key result
Replacing H2O with D2O in frog single muscle fibres resulted in a rapid large reduction of peak twitch tension and speed of tension development, and increased the curvature of the force-velocity relation.
Population
Single muscle fibres isolated from the semitendinosus muscle of the frog
Comparison
Deuterium oxide treatment vs H2O-Ringer solution
Design
Preclinical
Authors
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D2O effects on frog fiber twitch warrant caution against clinical extrapolation; leaves open relevance to mammalian cardiac or skeletal muscle mechanics.
D2O treatment depresses twitch and tetanic tension development in frog muscle fibers, likely by affecting the rate-limiting release of Ca2+ from the sarcoplasmic reticulum.
Cecchi et al. (1981) studied Isolated frog single muscle fibres. Deuterium oxide (D2O) vs. H2O-Ringer solution was evaluated on Force-velocity (P-V) relation and tension characteristics. Replacing H2O with D2O in frog single muscle fibres resulted in a rapid large reduction of peak twitch tension and speed of tension development, and increased the curvature of the force-velocity relation.
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