Why the study?
Does metoprolol reduce blood pressure and plasma renin activity in patients with essential hypertension?
Population
16 patients with essential hypertension
Comparison
Metoprolol 25 mg three times daily for 1 week… vs Placebo
Design
Other
Follow-up
6 weeks
Authors
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Metoprolol was associated with BP reduction in essential hypertension; leaves open renin-dependent response prediction.
Does metoprolol reduce blood pressure and plasma renin activity in patients with essential hypertension?
Metoprolol effectively lowers blood pressure and plasma renin activity in essential hypertension, with the blood pressure reduction correlating with baseline plasma renin activity rather than steady-state metoprolol levels.
Bahr et al. (1976) studied this question.