Key result
Lipoprotein lipase, hepatic lipase, and endothelial lipase exhibit both pro- and antiatherogenic properties that are dependent primarily on their tissue localization in murine models.
Lipases have complex, tissue-specific pro- and antiatherogenic roles in murine models of atherosclerosis.
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Tissue-specific lipase effects in mice caution against systemic targeting in humans; leaves open targeted human validation studies.
Lipoprotein lipase, hepatic lipase, and endothelial lipase are sn-1 lipases that play important roles in the metabolism of plasma lipoproteins. In vitro and in vivo studies suggest that these lipases exhibit both pro- and antiatherogenic properties, which are dependent primarily on their tissue localization. The following chapter reviews the physiology of these lipases, and the consequences of the loss or gain of function for each lipase in modulating atherosclerosis, with emphasis on murine models.
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Brown et al. (2007) conducted a review in Atherosclerosis. Lipases (Lipoprotein lipase, hepatic lipase, and endothelial lipase) was evaluated on Modulation of atherosclerosis. Lipoprotein lipase, hepatic lipase, and endothelial lipase exhibit both pro- and antiatherogenic properties that are dependent primarily on their tissue localization in murine models.
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