Key result
Out-of-hospital cardiac arrest survivors had similar rates of low self-reported physical activity compared to matched myocardial infarction controls (25% vs. 20%, P=0.13) at 7 months.
Why the study?
To determine whether OHCA survivors have lower self-reported physical activity levels than MI controls without cardiac arrest, and whether anxiety, depression, kinesiophobia, or fatigue correlate with low activity.
Do out-of-hospital cardiac arrest survivors have lower levels of self-reported physical activity compared to matched myocardial infarction controls?
Case-Control (n=197)
Yes
Do out-of-hospital cardiac arrest survivors have lower levels of self-reported physical activity compared to matched myocardial infarction controls?
Absolute Event Rate: 25% vs 20%
p-value: p=0.13
Out-of-hospital cardiac arrest survivors have similar levels of physical activity compared to matched MI controls at 7 months, although they experience significantly more kinesiophobia.
Does not support distinct physical activity guidance for OHCA survivors; leaves open need for prospective trials on recovery interventions.
AIMS: To investigate whether out-of-hospital cardiac arrest (OHCA) survivors had lower levels of self-reported physical activity compared to a non-cardiac arrest control group with myocardial infarction (MI), and to explore if symptoms of anxiety, depression, kinesiophobia (fear of movement), and fatigue were associated with a low level of physical activity. METHODS AND RESULTS: Pre-defined case-control sub-study within the international Targeted Hypothermia versus Targeted Normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial. Out-of-hospital cardiac arrest survivors at 8 of 61 TTM2 sites in Sweden, Denmark, and the UK were invited. Participants were matched 1:1 to MI controls. Both OHCA survivors and MI controls answered two questions on self-reported physical activity, categorized as a low, moderate, or high level of physical activity, and questionnaires on anxiety and depression symptoms, kinesiophobia, and fatigue 7 months after the cardiac event. Overall, 106 of 184 (58%) eligible OHCA survivors were included and matched to 91 MI controls. In total, 25% of OHCA survivors and 20% of MI controls reported a low level of physical activity, with no significant difference (P = 0.13). Symptoms of kinesiophobia and fatigue were significantly associated with a low level of physical activity in both groups. Out-of-hospital cardiac arrest survivors had significantly more kinesiophobia compared to MI controls (18% vs. 9%, P = 0.04), while levels of anxiety and depression symptoms and fatigue were similar. CONCLUSION: Out-of-hospital cardiac arrest survivors had similar levels of physical activity compared to matched MI controls. High level of kinesiophobia and fatigue were associated with a low level of physical activity in both groups. REGISTRATION: ClinicalTrials.gov: NCT03543332.
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Heimburg et al. (2025) conducted a case-control in Out-of-hospital cardiac arrest (n=197). Out-of-hospital cardiac arrest vs. Myocardial infarction without cardiac arrest was evaluated on Low level of self-reported physical activity (p=0.13). Out-of-hospital cardiac arrest survivors had similar rates of low self-reported physical activity compared to matched myocardial infarction controls (25% vs. 20%, P=0.13) at 7 months.
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