Why the study?
Does tempol or hydralazine reduce renal injury and MAPK activity in Dahl salt-sensitive hypertensive rats?
Population
Dahl salt-sensitive hypertensive rats
Comparison
Tempol or hydralazine added to high salt diet… vs High salt diet alone or low salt diet alone
Design
Preclinical
Follow-up
4 weeks
Authors
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Does not support clinical use; extends preclinical evidence implicating ROS-MAPK pathways in salt-sensitive renal injury.
Does tempol or hydralazine reduce renal injury and MAPK activity in Dahl salt-sensitive hypertensive rats?
In a rat model of salt-sensitive hypertension, the superoxide dismutase mimetic tempol ameliorated renal injury and reduced MAPK activity, suggesting reactive oxygen species contribute to renal damage via ERK1/ERK2 activation.
Nishiyama et al. (2004) studied this question.
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