Why the study?
Does the superoxide dismutase mimetic Tempol reduce arterial pressure and renal damage in Dahl salt-sensitive rats?
Population
43 Dahl salt-sensitive rats
Comparison
3-week intravenous infusion of the superoxide… vs 3-week intravenous infusion of low Na or high Na…
Design
Preclinical
Follow-up
3 weeks
Authors
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Supports oxidative stress role in experimental salt-sensitive hypertension; leaves open human translation.
Does the superoxide dismutase mimetic Tempol reduce arterial pressure and renal damage in Dahl salt-sensitive rats?
Tempol, a superoxide dismutase mimetic, attenuates hypertension and renal damage in Dahl salt-sensitive rats on a high-sodium diet, suggesting oxidative stress plays a key role in salt-sensitive hypertension.
Meng et al. (2003) studied this question.
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