February 28, 2006HypertensionOpen Access

NADPH Oxidase in the Renal Medulla Causes Oxidative Stress and Contributes to Salt-Sensitive Hypertension in Dahl S Rats

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Why the study?

Does NADPH oxidase inhibition with apocynin reduce renal medullary superoxide and mean arterial pressure in Dahl salt-sensitive rats?

Structured PICO

Does NADPH oxidase inhibition with apocynin reduce renal medullary superoxide and mean arterial pressure in Dahl salt-sensitive rats?

Population

Prehypertensive Dahl salt-sensitive (SS) rats and consomic, salt-resistant SS-13BN rats fed a 0.4% NaCl diet

Intervention

NADPH oxidase inhibitor apocynin (3.5 microg/kg per minute) chronically delivered directly into the renal medulla during a 4% NaCl diet

Comparator

Absence of apocynin (control)

Outcome

Renal medullary interstitial superoxide levels and mean arterial pressuresurrogate

Excess renal medullary superoxide production mediated by NADPH oxidase contributes to salt-induced hypertension in Dahl salt-sensitive rats.

No takes yet. Share an insight, caveat, or question.

NADPH oxidase inhibition merits further mechanistic study in salt-sensitive hypertension; leaves open clinical translation from this animal model.

Taylor et al. (2006) studied this question.

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NADPH oxidase inhibition merits further mechanistic study in salt-sensitive hypertension; leaves open clinical translation from this animal model.