Key result
Treatment with imidapril significantly reduced kidney lipid peroxidation (0.16 vs 0.33 nmol/mg protein, P<0.001) and urinary hydrogen peroxide in Dahl salt-sensitive rats with heart failure.
Why the study?
Does imidapril reduce oxidative stress and renal damage in Dahl salt-sensitive rats with heart failure?
Population
11-week-old Dahl salt-sensitive (DS) rats fed an 8%-NaCl diet with heart failure (DSHF)
Comparison
Imidapril (1 mg/kg per day) for 7 weeks vs Vehicle
Design
Preclinical
Follow-up
7 weeks
Authors
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Does not support clinical use in heart failure; leaves open whether imidapril reduces renal oxidative stress in humans.
Does imidapril reduce oxidative stress and renal damage in Dahl salt-sensitive rats with heart failure?
Absolute Event Rate: 0.16% vs 0.33%
p-value: p=<0.001
Blockade of local angiotensin II with a subpressor dose of imidapril inhibits NAD(P)H oxidase and prevents renal damage in a rat model of heart failure.
Tojo et al. (2002) studied Heart failure. Imidapril vs. Vehicle was evaluated on Kidney lipid peroxidation product (p=<0.001). Treatment with imidapril significantly reduced kidney lipid peroxidation (0.16 vs 0.33 nmol/mg protein, P<0.001) and urinary hydrogen peroxide in Dahl salt-sensitive rats with heart failure.
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