Why the study?
Does imidapril improve myocardial remodeling and alter NOS expression in a rat model of hypertensive heart failure?
Population
Dahl salt-sensitive hypertensive rats fed an 8% NaCl diet developing left ventricular hypertrophy and…
Comparison
Imidapril 1 mg/kg/day administered for 7 weeks vs Vehicle and age-matched Dahl salt-resistant rats…
Design
Preclinical
Follow-up
7 weeks
Authors
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Imidapril effects on remodeling and NOS in rat hypertensive HF are hypothesis-generating; human translation remains untested.
Does imidapril improve myocardial remodeling and alter NOS expression in a rat model of hypertensive heart failure?
In a rat model of hypertensive heart failure, imidapril improved myocardial remodeling and cardiac function, associated with increased eNOS and decreased iNOS expression.
Naohiko Kobayashi (1999) studied this question.
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