Why the study?
Does imidapril improve cardiac function and prevent changes in sarcoplasmic reticulum protein gene expression in rats with MI-induced congestive heart failure?
Population
Rats with congestive heart failure induced by myocardial infarction (coronary artery occlusion)
Comparison
Imidapril given for 4 weeks starting 3 weeks… vs Untreated infarcted rats
Design
Preclinical
Follow-up
4 weeks
Authors
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Hypothesis-generating in rat MI model; leaves open translation to human HF therapy.
Does imidapril improve cardiac function and prevent changes in sarcoplasmic reticulum protein gene expression in rats with MI-induced congestive heart failure?
Blockade of the renin-angiotensin system with imidapril improves cardiac function in a rat model of MI-induced heart failure by preserving sarcoplasmic reticulum Ca2+ transport and related gene expression.
Shao et al. (2004) studied this question.
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