Population
Hypertensive Dahl salt-sensitive (SS) rats and inbred consomic control strain (SS-13(BN)) fed a 4% salt diet
Comparison
l-nitroarginine methyl ester inhibition of NOS vs Consomic SS-13(BN) rats
Design
Preclinical
Authors
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Indicates NOS uncoupling in salt-sensitive rat hypertension; hypothesis-generating for human translation.
NOS uncoupling driven by a shift of BH4 to BH2 contributes to elevated reactive oxygen species in the renal medulla of hypertensive salt-sensitive rats.
Taylor et al. (2006) studied this question.
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