Key result
A low ΔV'O2/ΔWR relationship during exercise in patients with COPD and heart failure was associated with ~15% lower peak work rate and ~30% lower peak oxygen uptake (p<0.05).
Why the study?
Impaired aerobic function is a potential mechanism of exercise intolerance in patients with combined cardiorespiratory disease, but the consequences of a low delta V'O2/deltaWR relationship during exercise remained unclarified.
Does a low change in oxygen uptake/change in work rate relationship correlate with worse exercise intolerance and pathophysiological consequences in patients with comorbid COPD and systolic heart failure?
Population
51 clinically stabilized patients with coexisting COPD and systolic HF
Comparison
Low delta V'O2/deltaWR vs normal delta V'O2/deltaWR during exercise
Design
Observational cross-sectional study
Authors
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Low ΔV'O2/ΔWR may flag reduced exercise capacity in COPD-HF overlap; leaves open its prognostic utility pending validation.
Observational (n=51)
Does a low change in oxygen uptake/change in work rate relationship correlate with worse exercise intolerance and pathophysiological consequences in patients with comorbid COPD and systolic heart failure?
p-value: p=<0.05
Impaired aerobic function, indicated by a low Δ V ′ O 2 /ΔWR relationship, is a key determinant of exercise intolerance in patients with comorbid COPD and systolic heart failure.
Rocha et al. (2019) conducted an observational in Coexisting chronic obstructive pulmonary disease (COPD) and systolic heart failure (HF) (n=51). Low change in oxygen uptake/change in work rate (ΔV'O2/ΔWR) relationship vs. Normal ΔV'O2/ΔWR relationship was evaluated on Peak work rate and peak oxygen uptake (p=<0.05). A low ΔV'O2/ΔWR relationship during exercise in patients with COPD and heart failure was associated with ~15% lower peak work rate and ~30% lower peak oxygen uptake (p<0.05).
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