Key result
In pregnant women with mechanical heart valve prostheses, prophylactic anticoagulation with warfarin was associated with high complication rates, including 20% miscarriages, 10% stillbirths, and 4 cases of warfarin embryopathy.
Observational (n=61)
No
Prophylactic anticoagulation with warfarin in pregnant women with mechanical heart valves in an under-resourced setting is associated with high rates of maternal and fetal complications, highlighting the need for alternative regimens and close monitoring.
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High fetal risks with warfarin in this cohort warrant close monitoring and alternatives; leaves optimal regimens open for prospective study.
Mazibuko et al. (2012) conducted an observational in Pregnant women with prosthetic heart valves (n=61). Prophylactic anticoagulation (primarily warfarin) was evaluated on Obstetric outcomes and maternal complications. In pregnant women with mechanical heart valve prostheses, prophylactic anticoagulation with warfarin was associated with high complication rates, including 20% miscarriages, 10% stillbirths, and 4 cases of warfarin embryopathy.
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