Why the study?
Does omeprazole prevent aspirin induced gastric mucosal injury in normal subjects?
Population
Normal human subjects
Design
RCT, Randomised crossover design according to latin square, Double blind
Authors
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Supports PPI co-therapy with aspirin to lower GI injury risk; confirms benefit in healthy volunteers and warrants patient outcome trials.
Does omeprazole prevent aspirin induced gastric mucosal injury in normal subjects?
Omeprazole prevents aspirin-induced gastric mucosal injury in normal subjects, suggesting a strategy to prevent peptic ulcers in patients taking aspirin and other NSAIDs.
Daneshmend et al. (1990) studied this question.
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