The Prevalence and Significance of the Early Repolarization Pattern in Sudden Arrhythmic Death Syndrome Families
Key result
Early repolarization patterns were more common in sudden arrhythmic death syndrome family members than in controls (21% vs 8%; OR 5.14; 95% CI 3.37-7.84).
Why the study?
Is the early repolarization pattern more prevalent in first-degree relatives of individuals who died from sudden arrhythmic death syndrome compared to controls?
Population
401 first-degree relatives of individuals who had died from sudden arrhythmic death syndrome (SADS)
Comparison
Presence of early repolarization pattern on… vs Family-clustered controls
Design
Case-control
Authors
Discussion
Loading...
Member takes
Implication
Early repolarization may mark familial SADS risk; hypothesis-generating for screening utility.
Study Design
Type
Case-Control (n=401)
Structured PICO
Is the early repolarization pattern more prevalent in first-degree relatives of individuals who died from sudden arrhythmic death syndrome compared to controls?
P
Population
401 first-degree relatives of individuals who died from sudden arrhythmic death syndrome compared with family-clustered controls.
E
Exposure
Presence of early repolarization (ER) pattern on 12-lead ECG
C
Comparator
Family-clustered controls
O
Outcome
Prevalence of early repolarization (ER) patternssurrogate
Main Result
Odds Ratio: 5.14 (95% CI 3.37–7.84)
Absolute Event Rate: 21% vs 8%
The early repolarization pattern is significantly more prevalent in relatives of SADS victims, suggesting it may represent a heritable arrhythmia syndrome or risk factor for sudden death.
Cite This Study
Mellor et al. (2016) conducted a case-control in Sudden arrhythmic death syndrome (SADS) (n=401). SADS family member vs. Family-clustered controls was evaluated on Prevalence of early repolarization (ER) patterns (OR 5.14, 95% CI 3.37-7.84). Early repolarization patterns were more common in sudden arrhythmic death syndrome family members than in controls (21% vs 8%; OR 5.14; 95% CI 3.37-7.84).