Key result
Elevated HALP score is linked to ~27.9-fold higher odds of dyslipidemia.
Why the study?
Dyslipidemia is a major risk factor for cardiovascular disease, but there is no information on the association of the HALP score with dyslipidemia.
Is an elevated HALP score associated with the presence of dyslipidemia?
Cross-Sectional (n=7,192)
Is an elevated HALP score associated with the presence of dyslipidemia?
The HALP score is an easily accessible immunonutritional biomarker that is significantly elevated in patients with dyslipidemia and may assist in risk assessment for lipid abnormalities.
Answers are grounded in this paper and cite their sources.
May support HALP score for dyslipidemia risk assessment; leaves open validation in prospective cohorts.
Background and Objectives: Dyslipidemia is a major risk factor for cardiovascular disease (CVD). The identification of new biomarkers that may enhance the risk assessment of lipid abnormalities is a promising approach in improving risk prediction of CVD. There is no information on the association of the hemoglobin, albumin, lymphocyte, and platelet (HALP) score with dyslipidemia. The aim of this study was to investigate the clinical utility of the HALP score in light of dyslipidemia. Materials and Methods: A retrospective analysis of 7192 subjects was initiated to assess the association between the HALP score and disturbed lipid markers. Medians were compared by Mann–Whitney U or Kruskal–Wallis tests and the diagnostic performance and risk assessment were calculated. Results: Median HALP score among all subjects was 53.3, with varying values between males and females. Notably, median HALP was significantly elevated in all forms of dyslipidemia and among males and females irrespective of age. The odds of having elevated HALP score values were significantly higher in all lipid abnormalities. Moreover, HALP score was significantly yet weakly correlated with lipid markers, while the highest diagnostic accuracy of the HALP score was observed with an elevated ratio of total cholesterol to high-density lipoprotein (TC/HDL) (area under the curve, AUC = 0.6411, p < 0.0001). The decision curve analysis (DCA) showed that the HALP score can reliably predict the presence of dyslipidemia. Conclusions: This study demonstrates that the HALP score is a novel, cost-effective index that is associated with a disturbed lipid profile. Further investigation of the nature of this association is needed.
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Alshuweishi et al. (2023) conducted a cross-sectional in Dyslipidemia (n=7,192). High HALP score (>58.59) vs. Normal HALP score (≤58.59) was evaluated on Presence of dyslipidemia (OR 27.9, 95% CI 17.1-46.2, p=<0.001). An elevated HALP score was highly associated with the presence of dyslipidemia.
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