Key result
An early reduction in oxygen free radicals after carvedilol administration in post-MI heart failure patients was associated with greater functional class improvement at 6 months (79.3% vs 10%, P<0.01).
Why the study?
Does the early anti-oxidant effect of carvedilol predict the clinical course in post-myocardial infarction congestive heart failure patients?
Population
39 recent myocardial infarction patients with congestive heart failure, mean age 60.5 +/- 7 years, NYHA…
Design
Cohort
Follow-up
6 months to 1 year
Authors
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Early radical reduction may predict carvedilol responders in post-MI HF; hypothesis-generating and requires prospective validation.
Cohort (n=39)
Does the early anti-oxidant effect of carvedilol predict the clinical course in post-myocardial infarction congestive heart failure patients?
Absolute Event Rate: 79.3% vs 10%
p-value: p=<0.01
The early anti-oxidant response to carvedilol in post-myocardial infarction heart failure patients may serve as a predictor for long-term clinical and functional improvement.
Goldhammer et al. (2007) conducted a cohort in Post-myocardial infarction congestive heart failure (n=39). Early reduction in oxygen free radicals following carvedilol administration vs. No change in oxygen free radicals was evaluated on Functional class improvement at 6 months (p=<0.01). An early reduction in oxygen free radicals after carvedilol administration in post-MI heart failure patients was associated with greater functional class improvement at 6 months (79.3% vs 10%, P<0.01).
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