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March 27, 2019Expert Review of Anticancer Therapy

Early identification of subclinical cardiotoxicity using troponins and early treatment with ACE-inhibitors appear to be effective strategies to prevent cardiac dysfunction in cancer patients.

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Why the study?

As cancer treatment advances have improved survival, cardiotoxicity induced by oncologic therapies has become an important determinant of survival and quality of life.

Design

Review

Key result

Early identification of subclinical cardiotoxicity using troponins and early treatment with ACE-inhibitors appear to be effective strategies to prevent cardiac dysfunction in cancer patients.

Authors

DCDaniela CardinaleFSFederica StivalaCCCarlo M. Cipolla

Discussion

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Member takes

Overview

Supports troponin-guided early ACEI in cancer patients; hypothesis-generating pending randomized confirmation.

Structured PICO

P
Population
Cancer patients receiving oncologic therapies associated with cardiac toxicities
I
Intervention
Strategies to mitigate cardiotoxicity, including early detection with troponins and early treatment with ACE-inhibitors

Early identification of subclinical cardiotoxicity using troponins and prophylactic treatment with ACE-inhibitors may effectively prevent cardiac dysfunction in cancer patients.

Limitations

  • Current standard of cardiac monitoring identifies cardiotoxicity only when functional impairment has already occurred, precluding effective prevention.

Cite This Study

Cardinale et al. (2019) conducted a review in Cancer-therapy induced cardiotoxicity. Early identification with troponins and early treatment with ACE-inhibitors was evaluated. Early identification of subclinical cardiotoxicity using troponins and early treatment with ACE-inhibitors appear to be effective strategies to prevent cardiac dysfunction in cancer patients.

synapsesocial.com/papers/6a6f3025660549caf2c3bfcahttps://doi.org/10.1080/14737140.2019.1596804
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prevention and Treatment of Cardiotoxicity in Cancer Patients2025
  2. 2Using biomarkers and early prophylactic treatment to prevent cardiotoxicity in cancer patients on chemotherapy2017 · 1 citations
  3. 3An update on the risk prediction and prevention of anticancer therapy-induced cardiotoxicity2014 · 11 citations
  4. 4Cardiotoxicity of Targeted Therapies in Non-Hematologic Cancers: Mechanisms, Risks and Monitoring2025
  5. 5Using biomarkers to predict and to prevent cardiotoxicity of cancer therapy2017 · 95 citations