What question did this study set out to answer?

To determine whether circulating luteinizing hormone (LH) pulse frequency or pulse amplitude is altered in women with polycystic ovary syndrome.

August 1, 1987The Journal of Clinical Endocrinology & Metabolism

Circulating Luteinizing Hormone Pulse Frequency in Women with Polycystic Ovary Syndrome*

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To determine whether circulating luteinizing hormone (LH) pulse frequency or pulse amplitude is altered in women with polycystic ovary syndrome.
Measured serum LH concentrations every 10 minutes over a 12-hour period (0800–2000 h) in nine women with polycystic ovary syndrome (N=9).
Compared hormonal secretory patterns against nine control evaluations obtained from six normally cycling women (N=6) during the early follicular and midfollicular phases.
Mean LH pulse frequency in polycystic ovary syndrome (12.1 ± 0.7 pulses/12 h) was indistinguishable from normal early follicular (12.1 ± 0.4 pulses/12 h) and midfollicular controls (12.0 ± 0.7 pulses/12 h).
Mean LH pulse amplitude was significantly higher in polycystic ovary syndrome patients (12.2 ± 2.7 mIU/mL) compared to controls in both early follicular (6.2 ± 0.8 mIU/mL) and midfollicular phases (6.4 ± 0.6 mIU/mL; P < 0.05).

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Implication

Comparative study demonstrates elevated luteinizing hormone pulse amplitude without altered pulse frequency in polycystic ovary syndrome, suggesting increased burst size drives hypersecretion.

Cite This Study

Kazer et al. (1987) studied this question.

synapsesocial.com/papers/6a6f322926a7f98052dbeef6 https://doi.org/10.1210/jcem-65-2-233

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Implication

Comparative study demonstrates elevated luteinizing hormone pulse amplitude without altered pulse frequency in polycystic ovary syndrome, suggesting increased burst size drives hypersecretion.

Circulating Luteinizing Hormone Pulse Frequency in Women with Polycystic Ovary Syndrome*

Key Points

Discussion

Implication

Cite This Study

Circulating Luteinizing Hormone Pulse Frequency in Women with Polycystic Ovary Syndrome*

Key Points

Discussion

Implication

Cite This Study

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