Key result
Caffeinated high-fructose corn syrup soda fails to alter arterial stiffness acutely compared to water.
Why the study?
To test the hypothesis that ingestion of a caffeinated soft drink sweetened with high-fructose corn syrup acutely increases arterial stiffness.
Does acute ingestion of a caffeinated soft drink sweetened with high-fructose corn syrup increase arterial stiffness in healthy young adults?
RCT (n=14)
Open-label
Randomized counterbalanced, crossover design in blocks of two
No
Does acute ingestion of a caffeinated soft drink sweetened with high-fructose corn syrup increase arterial stiffness in healthy young adults?
Acute ingestion of a typical serving of a caffeinated, high-fructose corn syrup-sweetened soft drink does not immediately worsen systemic arterial stiffness or hemodynamics in healthy, young adults.
No acute cfPWV rise after caffeinated HFCS drink; reassures on occasional intake in healthy young adults while extending acute RCT hemodynamic data.
We tested the hypothesis that ingestion of a caffeinated soft drink sweetened with high-fructose corn syrup acutely increases arterial stiffness. In a randomized counterbalanced, crossover design, fourteen healthy adults (25 ± 3 years, 6 women) reported to the laboratory for two experimental visits where 500 ml of tap water (H2O) or 500 ml of Mountain Dew® (a caffeinated soft drink sweetened with high-fructose corn syrup (HFCS)) were consumed. Arterial stiffness (carotid-to-femoral pulse wave velocity (cfPWV)), peripheral and central blood pressures were measured pre-consumption, 30 min post-consumption, and 120 min post-consumption. Prior to each measurement period, beat-to-beat hemodynamic measures were collected. Changes in heart rate, blood pressure, and cardiac output from pre-consumption did not differ between trials at any timepoint (p ≥ 0.06). Moreover, changes in peripheral or central blood pressures from pre-consumption did not differ between trials (p ≥ 0.84). Likewise, changes in cfPWV from pre-consumption to 30 min post-consumption (HFCS: 0.2 ± 0.3 m/s, H2O: 0.0 ± 0.3 m/s, p = 0.34) and 120 min post-consumption (HFCS: 0.3 ± 0.4 m/s, H2O: 0.2 ± 0.3 m/s, p = 0.77) did not differ. Changes in aortic augmentation pressure, augmentation index, augmentation index corrected to a heart rate of 75 bpm, and reflection magnitude did not differ between conditions at 30 min post- (p ≥ 0.55) or 120 min post- (p ≥ 0.18) consumption. In healthy young adults, ingesting 500 ml of a commercially available caffeinated soft drink sweetened with high-fructose corn syrup does not acutely change indices of arterial stiffness and wave reflection.
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Freemas et al. (2021) conducted an RCT in Healthy adults (n=14). Caffeinated soft drink sweetened with high-fructose corn syrup (Mountain Dew) vs. 500 ml of tap water was evaluated on Change in carotid-to-femoral pulse wave velocity (cfPWV) at 30 minutes post-consumption (p=0.34). Ingesting 500 ml of a caffeinated soft drink sweetened with high-fructose corn syrup did not acutely change carotid-to-femoral pulse wave velocity at 30 minutes (p=0.34) or 120 minutes (p=0.77) post-consumption compared to water.
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