Key result
The ARTSENS Plus device showed excellent agreement with reference measures for carotid artery lumen diameter, local stiffness indices, and pulse wave velocity (absolute errors <4.1%, 9%, and 4.1%).
Why the study?
Devices facilitating combined assessment of vascular health markers, arterial stiffness, and blood pressure in clinical practice and large-scale screening settings were lacking.
Does the ARTSENS Plus image-free ultrasound device accurately measure local and regional vascular stiffness and central blood pressure compared to reference measures in asymptomatic individuals?
Cross-Sectional (n=90)
Does the ARTSENS Plus image-free ultrasound device accurately measure local and regional vascular stiffness and central blood pressure compared to reference measures in asymptomatic individuals?
The ARTSENS Plus image-free ultrasound device provides reliable and accurate evaluation of local and regional vascular stiffness and central blood pressure, meeting clinical standards.
Preclinical accuracy supports further device development; leaves open human validation for carotid assessment.
OBJECTIVE: The combined assessment of vascular health markers is crucial for identifying the cumulative burden of vascular risk factors early on, as well as the extent of vascular aging for effective prediction of future cardiovascular events. This work addresses the need for a currently nonexistent device or system that facilitates such combined assessment in clinical practice and large-scale screening settings. We report an image-free ultrasound device - ARTSENS Plus - developed for the measurement of local and regional arterial stiffness, central and peripheral blood pressure (BP), and vessel dimensions, all in one examination. METHODS: A preclinical study on 90 asymptomatic individuals verified the device's functionality under ARTERY Society guidelines. The device's accuracy of stiffness measures was validated against the reference measures. RESULTS: The interoperator and intraoperator variability was less than 7%. Carotid artery's lumen diameter and local stiffness indices and carotid-femoral regional pulse wave velocity showed excellent agreement with the references (absolute errors were less than 4.1, 9, and 4.1%, respectively). The carotid SBP was 10.02% lower than that of the brachial artery, as expected. CONCLUSION: The study demonstrated the device's ability to perform an effortless and reliable evaluation of the local and regional vascular stiffness and central BP with an accuracy that meets clinical standards.
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Nabeel et al. (2022) conducted a cross-sectional in Asymptomatic (n=90). ARTSENS Plus (image-free ultrasound device) vs. Reference measures was evaluated on Accuracy of stiffness measures (carotid artery lumen diameter, local stiffness indices, and carotid-femoral regional pulse wave velocity). The ARTSENS Plus device showed excellent agreement with reference measures for carotid artery lumen diameter, local stiffness indices, and pulse wave velocity (absolute errors <4.1%, 9%, and 4.1%).
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