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June 1, 1997Thyroid

Flow-Mediated, Endothelium-Dependent Vasodilatation Is Impaired in Subjects with Hypothyroidism, Borderline Hypothyroidism, and High-Normal Serum Thyrotropin (TSH) Values

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Why the study?

Is flow-mediated endothelium-dependent vasodilatation impaired in subjects with hypothyroidism, borderline hypothyroidism, and high-normal TSH levels?

Population

35 subjects with various TSH levels (hypothyroidism, borderline hypothyroidism, and high-normal serum TSH)

Design

Cross-sectional

Authors

JLJohn LekakisGeneral CardiologyCPChristos PapamichaelNational and Kapodistrian University of AthensMAMaria AlevizakiNational and Kapodistrian University of Athens

Discussion

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Implication

Lower FMD with TSH >2 μIU/mL may indicate early endothelial impairment; hypothesis-generating for prospective trials on thyroid therapy and atherosclerosis risk.

Structured PICO

Is flow-mediated endothelium-dependent vasodilatation impaired in subjects with hypothyroidism, borderline hypothyroidism, and high-normal TSH levels?

P
Population
35 subjects with various TSH levels (hypothyroidism, borderline hypothyroidism, and high-normal serum TSH)
C
Comparator
Subjects with normal TSH (0.4-2 microIU/mL)
O
Outcome
Flow-mediated, endothelium-dependent vasodilatation assessed by high-resolution ultrasound imaging of the brachial arterysurrogate

Endothelial function is impaired not only in clinical hypothyroidism but also in subjects with high-normal TSH levels, suggesting an early increased risk for atherosclerosis.

Cite This Study

Lekakis et al. (1997) studied this question.

synapsesocial.com/papers/6a6f3338fe4101aa97dfb898https://doi.org/10.1089/thy.1997.7.411
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Flow-induced release of endothelium-derived relaxing factor1986 · 1,373 citations
  2. 2Early evidence of endothelial vasodilator dysfunction at coronary branch points.1990 · 136 citations
  3. 3Restoration of endothelium-dependent relaxation by dietary treatment of atherosclerosis.1987 · 354 citations
  4. 4Impairment of endothelium-dependent dilation is an early event in children with familial hypercholesterolemia and is related to the lipoprotein(a) level.1994 · 583 citations
  5. 5The incidence of thyroid disorders in the community: a twenty‐year follow‐up of the Whickham Survey1995 · 2,461 citations