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January 4, 2000Proceedings of the National Academy of SciencesOpen Access

Interaction of the poliovirus receptor with poliovirus

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Population

Poliovirus receptor (CD155) complexed with poliovirus (serotype 1)

Design

Preclinical

Authors

YHYongning HeShanghai Jiao Tong UniversityVBValorie D. BowmanPurdue University West LafayetteSMSteffen MuellerCodagenix (United States)

Discussion

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Implication

May elucidate picornavirus uncoating triggers; leaves open clinical translation from animal models.

Structured PICO

P
Population
Poliovirus receptor (CD155) complexed with poliovirus (serotype 1)
I
Intervention
Cryo-electron microscopy and three-dimensional image-reconstruction techniques
O
Outcome
Structure of the extracellular, three-domain poliovirus receptor (CD155) complexed with poliovirus

The structural determination of the poliovirus receptor complex reveals the binding site in the viral canyon, which may trigger the uncoating step required for infection.

Cite This Study

He et al. (2000) studied this question.

synapsesocial.com/papers/6a6f3552ac440176ef27eab7https://doi.org/10.1073/pnas.97.1.79
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Poliovirus can enter and infect mammalian cells by way of an intercellular adhesion molecule 1 pathway.1991 · 88 citations
  2. 2Mutational analysis of the cellular receptor for poliovirus1991 · 30 citations
  3. 3Cold-adapted poliovirus mutants bypass a postentry replication block1997 · 47 citations
  4. 4Improved methods for building protein models in electron density maps and the location of errors in these models1991 · 12,688 citations