Treatment of patients with multiple organ dysfunction syndrome (MODS) with an electromagnetic field coupled to biorhythmically defined impulse configuration: the MicrocircMODS study

Figures

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  Fig. 1. Physical Vascular Therapy BEMER®—Placement of the mat “B.BODY Pro” for whole body treatment of the study patient. For further explanation, see “Methods”

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  Fig. 2. Study concept of the MicrocircMODS Study. For further explanation, see Table 1. MTP measurement time point; PVT Physical Vascular Therapy BEMER® (field intensity: day 1: 10.5 μT, day 2: 14.0 μT, day 3: 17.5 μT, day 4: 21.0 μT); SDF sublingual sidestream dark-field monitoring (Microscan®); TTP therapy time point

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  Fig. 3. Flow sheet of the MicrocircMODS study. Patient no. 6 was screened and registered but could not be included in the study because of a screening mistake (withdrawal of invasive cardiac output measurement in the interval from inclusion of the patient/reporting to the coordination centre for clinical trials and starting Physical Vascular Therapy BEMER® (PVT)). Patient nos. 2, 3, 4, 5, 7, 9 and 10 completed all 12 PVTs (4 days, three times a day). Patient number 1 received two PVTs on day 1, three PVTs on day 2 and one PVT on day 3; thereafter, patient had to be transferred to the surgery department for a disease-related emergency operation. Patient number 8 received three PVTs on day 1 and day 2; before the first PVT was intended to be given on day 3, the patient died from MODS and septic shock. IT Intention-to-Treat Group, PP Per-Protocol Group, PVT Physical Vascular Therapy BEMER®

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  Fig. 4. Effect of Physical Vascular Therapy BEMER® (PVT) in MODS patients on sublingual microcirculation—Follow-up of first 8-min-treatment episode on day 1 (upper graph) and during the 4-day treatment (lower graph). Data are given in the ordinate as relative median values for total vascular density (TVD) (“all” = all vessels”; “small” = vessels ≤ 20 μm in diameter; “non-small = vessels > 20 μm in diameter) and microvascular flow index (MFI) (see inset). Baseline value on day 1 before PVT is set as 100%. Relative median values given in percent refer to the value of the specific measurement time point (MTP) in relation to baseline value on day 1 before 1st PVT. For median values and interquartile range (IQR) values, see Table 3. For specification of “Measurement Time Points” (MTP) see Table 1

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  Fig. 5.. 4-day Physical Vascular Therapy BEMER® (PVT; day 1–day 4; 3 treatments per day; ↓) and global haemodynamics of MicrocircMODS study patients (A)—Comparison with the data from historical control MODS patients (MODIfY trial [22]) (B). A Ordinate: Haemodynamic data (see inset) are given as relative median values, with the value before the first PVT on day 1 (“Baseline”) set as 100%. Abscissa: “Baseline” = Day 1 Baseline (09,00 a.m.) immediately before 1st PVT (MTP 1); “Day 2” = Day 2 Baseline (09.00 a.m.) before 1st PVT (MTP 9); “Day 3” = Day 3 Baseline (09.00 a.m.) before 1st PVT (MTP 17); “Day 4” = Day 4 Baseline (09.00 a.m.) before 1st PVT (MTP 25); “Day 5” = Day 5 Baseline (09.00 a.m), first measurement after last (3rd) PVT on day 4) (MTP 32). B Ordinate: Haemodynamic data (see inset) are given as relative median values, with the value on day 1 (“Baseline”) set as 100%. Abscissa: Measurements during the first five days after inclusion of MODS patients in the MODIfY trial [22]. ACP Afterload-related Cardiac Performance, CPI Cardiac Power Index, CI Cardiac Index, HR Heart Rate, MAP Mean Arterial Pressure, MTP Measurement Time Point (see Table 1), PVT Physical Vascular Therapy…