June 1, 1991The Journal of PhysiologyOpen Access

Diastolic, systolic and sarcoplasmic reticulum Ca2+ during inotropic interventions in isolated rat myocytes.

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Population

Myocytes isolated from the ventricles of rat hearts

Design

Preclinical

Authors

JFJames E. FramptonHammersmith Hospital COClive H. OrchardElectrophysiology MBMark R. BoyettElectrophysiology

Discussion

Member takes

Implication

Elevated diastolic calcium may drive SR loading and larger transients in rat myocytes; hypothesis-generating for inotropy, leaves open human translation.

Structured PICO

Population

Myocytes isolated from the ventricles of rat hearts

Intervention

Changes in stimulation rate, bathing [Ca2+], and application of ryanodine (1 mumol l-1) or caffeine (10 mmol l-1)

Outcome

Diastolic intracellular [Ca2+], systolic intracellular [Ca2+], and sarcoplasmic reticulum Ca2+ contentsurrogate

The study demonstrates that in rat ventricular myocytes, increased diastolic intracellular calcium leads to increased sarcoplasmic reticulum calcium content and larger calcium transients during inotropic interventions.

Cite This Study

Frampton et al. (1991) studied this question.

synapsesocial.com/papers/6a6f3b592163a0a01bc38f40 https://doi.org/10.1113/jphysiol.1991.sp018600

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Implication

Elevated diastolic calcium may drive SR loading and larger transients in rat myocytes; hypothesis-generating for inotropy, leaves open human translation.