P712Clinical and hemodynamic outcomes up to 11 years after percutaneous pulmonary valve implantation

Background and purpose: Percutaneous pulmonary valve implantation (PPVI) has been a promising technique since the early 2000's, designed to innovate and improve the treatment right ventricular outflow tract obstruction (RVOT) and/or regurgitation. Normally, these kind of patients receive a homograft at the pulmonary position at a young age, due to i.e. pulmonary valve stenosis, pulmonary valve atresia or an absent valve with free flow. They are subject to multiple open heart surgeries, which are associated with risks of morbidity and mortality, since homografts only last for approximately fifteen years. A percutaneous way of implanting could postpone the necessity of yet another median sternotomy or thoracotomy. However, PPVI is a fairly new procedure and long term outcomes are quite unknown. This study aims to investigate the long-term clinical and hemodynamic outcomes. Methods: A multicenter retrospective, observational study was performed including all consecutive patients from May 2004 until November 2017. All clinical data, ECG and echocardiographic data were collected. Longitudinal serial gradient, regurgitation grade and QRS duration were analyzed using linear mixed effects models.