Key result
A short-term fat-free diet enhanced G-CSF-induced mobilization of hematopoietic stem/progenitor cells by depleting bone marrow ω3-fatty acids that normally activate PPARδ to suppress mobilization.
Why the study?
Hematopoietic stem/progenitor cell mobilization efficiency by G-CSF varies dramatically in humans and mice, with no established mechanistic lead for poor mobilizers.
Does a fat-free diet improve hematopoietic stem/progenitor cell mobilization in mice treated with G-CSF?
Population
Mice
Comparison
Fat-free diet vs normal diet
Design
Animal experimental study
Follow-up
2 weeks
Authors
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Hypothesis-generating for dietary optimization of stem cell mobilization; human trials needed before clinical consideration.
Does a fat-free diet improve hematopoietic stem/progenitor cell mobilization in mice treated with G-CSF?
Dietary fat restriction enhances G-CSF-induced hematopoietic stem cell mobilization by reducing PPARδ-mediated Angptl4 production in bone marrow neutrophils.
Suzuki et al. (2021) studied Hematopoietic stem/progenitor cell mobilization. Fat-free diet vs. Normal diet (4.69% fat) was evaluated on Mobilization efficiency (CFU-C and LSK cells in blood). A short-term fat-free diet enhanced G-CSF-induced mobilization of hematopoietic stem/progenitor cells by depleting bone marrow ω3-fatty acids that normally activate PPARδ to suppress mobilization.
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