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January 1, 1997Thrombosis and Haemostasis

The 20210 A Allele of the Prothrombin Gene Is a Common Risk Factor among Swedish Outpatients with Verified Deep Venous Thrombosis

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Why the study?

Does the 20210 A allele of the prothrombin gene increase the risk of venous thrombosis in Swedish outpatients?

Population

99 unselected Swedish outpatients with phlebography verified deep venous thrombosis, and 282 healthy controls

Comparison

Presence of the 20210 A allele of the… vs Absence of the 20210 A allele (healthy controls)

Design

Case-control

Authors

AHAndreas HillarpLund UniversityBZBengt ZöllerVascular / Pulmonary VascularPSPeter J. SvenssonGoethe University Frankfurt

Discussion

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Overview

Supports 20210A as independent venous thrombosis risk factor in outpatients; extends prior reports but leaves open screening utility.

Structured PICO

Does the 20210 A allele of the prothrombin gene increase the risk of venous thrombosis in Swedish outpatients?

P
Population
99 unselected Swedish outpatients with phlebography verified deep venous thrombosis, and 282 healthy controls
I
Intervention
Presence of the 20210 A allele of the prothrombin gene
C
Comparator
Absence of the 20210 A allele (healthy controls)
O
Outcome
Risk of venous thrombosishard clinical

The 20210 A allele of the prothrombin gene is a significant independent risk factor for deep venous thrombosis.

Cite This Study

Hillarp et al. (1997) studied this question.

synapsesocial.com/papers/6a6f3bbc5d37378ac1dc4ee3https://doi.org/10.1055/s-0038-1657674
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Deficiencies of Coagulation-Inhibiting and Fibrinolytic Proteins in Outpatients with Deep-Vein Thrombosis1990 · 449 citations
  2. 2A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis1996 · 3,130 citations
  3. 3Thromboembolic Disease – Critical Evaluation of Laboratory Investigation1992 · 113 citations
  4. 4Prothrombin fragment 1+2 and thrombin–antithrombin complex levels in patients with inherited APC resistance due to factor V Leiden mutation1996 · 64 citations
  5. 5An allosteric switch controls the procoagulant and anticoagulant activities of thrombin.1995 · 167 citations