Why the study?
Does a fixed daily minidose of warfarin (1 mg) reduce factor VII coagulant activity in healthy men with high baseline levels?
Population
42 healthy male Post Office workers with factor VII coagulant activity greater than 1.0 SD above the age…
Comparison
Warfarin 1 mg fixed daily minidose vs Placebo
Design
RCT, randomised, double-blind
Authors
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Supports outcome trials of minidose warfarin for IHD prevention; confirms factor VII reduction in men with high baseline levels.
Does a fixed daily minidose of warfarin (1 mg) reduce factor VII coagulant activity in healthy men with high baseline levels?
A fixed minidose of warfarin (1 mg daily) significantly reduces factor VII coagulant activity in healthy men with elevated baseline levels, suggesting potential utility in the primary prevention of ischemic heart disease.
Poller et al. (1990) studied this question.
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