Key result
In fatal myocardial infarction cases, MCP-1 and IL-15 were strongly expressed in the very early phase (0-4 hours) of ischemic injury, serving as reliable markers of early myocardial response compared to traumatic death controls.
Why the study?
Can immunohistochemical and Western blot quantification of inflammatory mediators (IL-15, MCP-1) accurately date the early inflammatory phase of myocardial infarction in fatal cases?
Population
Myocardial specimens from fatal myocardial infarction (MI) cases and control hearts from traumatic death cases
Comparison
Immunohistochemical evaluation and Western blot… vs Control hearts from traumatic death cases
Design
Case-control
Authors
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May aid forensic dating of early fatal MI; leaves open prospective validation before wider adoption.
Case-Control (n=51)
Blinded evaluators
Yes
Can immunohistochemical and Western blot quantification of inflammatory mediators (IL-15, MCP-1) accurately date the early inflammatory phase of myocardial infarction in fatal cases?
p-value: p=<0.001
IL-15 and MCP-1 are suitable early markers for dating the inflammatory response in the very early phase of myocardial infarction.
Turillazzi et al. (2014) conducted a case-control in Fatal myocardial infarction (n=51). Myocardial infarction (ischemic insult) vs. Traumatic death without pathological cardiac involvement was evaluated on Expression levels of inflammatory mediators (IL-15, MCP-1, CD15) in myocardial specimens (p=<0.001). In fatal myocardial infarction cases, MCP-1 and IL-15 were strongly expressed in the very early phase (0-4 hours) of ischemic injury, serving as reliable markers of early myocardial response compared to traumatic death controls.
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