Key result
Natriuretic peptide receptor C and its intracellular domain coupled to inhibitory G protein mediate biological effects participating in the pathophysiology of various cardiovascular diseases.
Why the study?
Although traditionally considered a clearance receptor, emerging evidence shows NPR-C mediates biological effects via Gi protein signaling in cardiovascular pathophysiology.
NPR-C functions beyond simple peptide clearance, acting through Gi-coupled signaling pathways to influence the pathophysiology of various cardiovascular diseases.
No immediate clinical implications; leaves open whether NPR-C modulation improves cardiovascular outcomes.
Natriuretic peptide (NP) system includes a group of peptides that regulate the balance of water and salt and maintain functional homeostasis of organs of the cardiovascular and several other systems. It includes atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP), which can bind to natriuretic peptide receptor C (NPR-C). NPR-C has been traditionally considered a NP clearance receptor responsible for natriuretic peptides degradation. However, there is increasing evidence that the intracellular domain of NPR-C is coupled to inhibitory G protein (Gi) which mediates many biological effects and participates in the pathophysiology of hypertension, atherosclerosis, coronary heart disease, arrhythmia, pulmonary hypertension, cardiac insufficiency and so on. This review focuses on the research progress in NPR-C and its related signaling pathways in hypertension and other cardiovascular diseases.
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Shao et al. (2022) conducted a review in Cardiovascular disease. Natriuretic peptide receptor C (NPR-C) was evaluated. Natriuretic peptide receptor C and its intracellular domain coupled to inhibitory G protein mediate biological effects participating in the pathophysiology of various cardiovascular diseases.
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