Key result
The monocarboxylic acid-derived Cl- channel blockers NPPB and NFA enhanced cardiac steady-state K+ current in rat ventricular myocytes, likely mediated by PKA and PTK signalling pathways.
Population
Rat ventricular myocytes
Comparison
Monocarboxylic acid-derived Cl channel blockers… vs Control conditions
Design
Preclinical
Authors
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May support off-target K+ current modulation by Cl- blockers in rodent myocytes; leaves open human relevance and clinical translation.
Monocarboxylic acid-derived Cl(-) channel blockers NPPB and NFA enhance cardiac steady-state K(+) currents via PKA and PTK signaling pathways in rat ventricular myocytes.
Zhou et al. (2007) studied this question. Monocarboxylic acid-derived Cl- channel blockers (NPPB and NFA) was evaluated on Cardiac depolarization-activated K+ currents. The monocarboxylic acid-derived Cl- channel blockers NPPB and NFA enhanced cardiac steady-state K+ current in rat ventricular myocytes, likely mediated by PKA and PTK signalling pathways.
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