Key result
Cl- channel blockers NPPB and NFA suppressed aconitine-induced arrhythmias in rat hearts and reversibly depressed the action potential upstroke with IC50 values of ~12.3 and ~73.1 microM, respectively.
Why the study?
Do Cl- channel blockers NPPB and NFA suppress aconitine-induced arrhythmias in rat hearts?
Population
Langendorff-perfused rat hearts and single rat cardiac ventricular myocytes
Design
Preclinical
Authors
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Hypothesis-generating for Cl- channel blockade in arrhythmia models; human translation untested.
Do Cl- channel blockers NPPB and NFA suppress aconitine-induced arrhythmias in rat hearts?
NPPB and NFA suppress aconitine-induced arrhythmias in rat hearts primarily by inhibiting cardiac sodium currents.
Zhou et al. (2005) studied Aconitine-induced arrhythmias. Cl- channel blockers (NPPB and NFA) was evaluated on Reversal of aconitine-induced arrhythmias and inhibition of sodium current (INa). Cl- channel blockers NPPB and NFA suppressed aconitine-induced arrhythmias in rat hearts and reversibly depressed the action potential upstroke with IC50 values of ~12.3 and ~73.1 microM, respectively.
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