July 1, 1993Journal of Cardiovascular Pharmacology

R 56 865, a Na+/Ca2+-Overload Inhibitor, Protects Against Aconitine-Induced Cardiac Arrhythmias In Vivo

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Why the study?

Does R 56 865 prevent aconitine-induced ventricular arrhythmias and mortality in anesthetized rats?

Population

Anesthetized rats (n = 10 for each compound) subjected to aconitine-induced arrhythmias

Comparison

Intravenous pretreatment with R 56 865 vs Saline control group

Design

Preclinical

Authors

HLHua Rong LuElectrophysiology FCFred De ClerckNovartis (Switzerland)

Discussion

Member takes

Implication

Supports Na+/Ca2+ overload inhibition in rat arrhythmia model; leaves open clinical translation.

Structured PICO

Does R 56 865 prevent aconitine-induced ventricular arrhythmias and mortality in anesthetized rats?

Population

Anesthetized rats (n = 10 for each compound) subjected to aconitine-induced arrhythmias

Intervention

Intravenous pretreatment with R 56 865 (1.25 mg/kg)

Comparator

Saline control group

Outcome

Incidence of aconitine-induced ventricular tachycardia (VT), ventricular fibrillation (VF), and mortalityhard clinical

In a rat model, the Na+/Ca2+-overload inhibitor R 56 865 significantly protected against aconitine-induced ventricular arrhythmias and mortality, highlighting the role of intracellular Na+ loading in arrhythmogenesis.

Cite This Study

Lu et al. (1993) studied this question.

synapsesocial.com/papers/6a9fc6e5fda9be3cfdefd63b https://doi.org/10.1097/00005344-199307000-00019

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R 56 865, a Na+/Ca2+-Overload Inhibitor, Protects Against Aconitine-Induced Cardiac Arrhythmias In Vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

R 56 865, a Na+/Ca2+-Overload Inhibitor, Protects Against Aconitine-Induced Cardiac Arrhythmias In Vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider